Dear Students,
Welcome to Developmental Biology MCQ – 03. This MCQ set consists of Advanced (Post Graduate Level) Developmental Biology / Embryology Multiple Choice Questions with Answer Key. All these questions were taken from the previous year question papers of CSIR JRF NET Life Sciences Examination. These questions can be used for the preparation of Competitive examinations in Biology / Life Sciences such as CSIR JRF NET, ICMR JRF, DBT BET JRF, GATE and other University Ph.D Entrance Examinations.
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(1). In chick, development of wing feather, thigh feather and claws depends on epithelial specificity conferred by induction from mesenchymal components from different sources of the dermins. This may be attributed to?
(a). Autocrine interaction
(b). Regional specificity of induction
(c). Receptor activation by hormones
(d). Inactivation of genetic interactions
Ans. (b)
(2). Alveolar cells of the lung arise from which one of the following layer(s)?
(a). Mesoderm
(b). Endoderm
(c). Ectoderm
(d). Both ectoderm and endoderm
Ans. (b)
(3). The following are statements regarding the development and maintenance of anterior and posterior compartments in each segment of Drosophila:
(A). Expression of wingless and engrailed is activated by pair-rule genes
(B). Continued expression of wingless and engrailed is maintained by interaction between the cells expressing Engrailed and Wingless proteins
(C). Hedgehog is expressed in wingless expressing cells and forms short range gradient
(D). Hedgehog is a transcription factor
(E). Engrailed is a secretory factor and binds with the patched receptor of the wingless expressing cells
Which one of the following combinations of above statements is correct?
(a). (C) and (E)
(b). (C), (D) and (E)
(c). (D) and (E)
(d). (A) and (B)
Ans. (d)
(4). In C. elegans, an anchor cell and a few hypodermal cells take part in the formation of vulva. The experiments performed to understand the role of these cells in vulva formation and the results obtained are as follows:
– If the anchor cell is killed by laser beam, hypodermal cells do not participate in vulva formation and no vulva develops.
– If six hypodermal cells closely located with anchor cell (called vulval precursor cells) are killed, no vulva develops.
– If the three central vulval precursors are destroyed, the three outer cells, which normally form hypodermis, take the fate of vulval cells instead.
Following are certain statements regarding vulva formation:
(A). Anchor cell acts as an inducer
(B). Six hypodermal cells with the potentiality to form vulva, form an equivalence group
(C). Three, out of six, hypodermal cells participate in vulva formation
(D). The central cell functions as the 1⁰ cell and the two cells on both side act as the 2⁰ cells
(E). The 1⁰ cell secretes a short range juxtacrine signal
Which combinations of the above statements have been derived from the above experimental results?
(a). (A), (B) and (C)
(b). (A), (B) and (D)
(c). (D) and (E)
(d) .(B), (D) and (E)
Ans. (a)
(5). The following are some important features which are commonly associated with animal development:
(A). Position of anus development with respect to blastopore
(B). Method of cell division
(C). Mechanism of coelom formation
(D). Cleavage pattern during egg development
Based on the above, which one of the following combinations differentiates the development of deuterostomes from that of protostomes?
(a). (A), (B) and (C)
(b). (B), (C) and (D)
(c). (A), (C) and (D)
(d). (A) and (B)
Ans. (c)
(6). Bones of vertebrates are derived from embryonic:
(a). Ectoderm
(b). Epiderm
(c). Mesoderm
(d). Endoderm
Ans. (c)
(7). During development, if a cell has committed to a particular fate, it is said to be:
(a). Pluripotent
(b). Totipotent
(c). Determined
(d). Differentiated
Ans. (c)
(8). The initial dorsal-ventral axis in amphibian embryos is determined by:
(a). The point of sperm entry.
(b). Gravity.
(c). The point of contact with the uterus.
(d). Genetic differences in the cells.
Ans. (a)
(9). Cadherins mediate Ca2+-dependent cell-cell adhesion and play an important role in embryonic development by changing the adhesive properties of cell. Aggregation of nerve cells to form an epithelium is correlated with the appearance of N-cadherins on cell surface and vice versa. N-CAM (neural cell adhesion molecules) belongs to Ig-SF (immunoglobulin super family) and involved in fine tuning of adhesive interactions. In order to see the effect of mutations of N-cadherin and N-CAM, two sets of mice were generated. Set A – mice with mutation in N-cadherin and set B – mice with mutation in N-CAM. Which of the following results is most likely to occur?
(a). Mice of both set A and set B will die in early development.
(b). Mice of set A will die in early development but mice of set B will develop normally and show mild abnormalities in the development of nervous system.
(c). Mice of Set A will show mild abnormalities in the development of nervous system whereas mice of set B will die early in development.
(d). Mice of both set A and set B develop normally as other cell adhesion molecules will compensate for the mutations.
Ans. (b)
(10). Which one of the following combinations is the correct pairing of ligands with their receptors?
(a). i – c, ii – a, iii – b
(b). i – a, ii – c, iii – b
(c). i – b, ii – c, iii – a
(d). i – c, ii – b, iii – a
Ans. (a)