What is Nucleotide Excision Repair (NER)? As the name suggests it is a type of DNA repair mechanism. In nucleotide excision repair or NER, the damaged base along with a short stretch of healthy strand is removed and later the gap is refilled with correct nucleotides. Thus the NER pathway operates by ‘cut and patch’ mechanism. Even though nucleotide excision […]
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DNA Repair: Part III – Base Excision Repair (BER) Mechanism
Cancer is a disease of the genome. And that’s what happens. You make mistakes in a cell somewhere in your body that causes it to start to grow when it should’ve stopped, and that’s cancer. And those mistakes are mistakes of DNA. Francis Collins What is Base Excision Repair or BER? As the name suggests, it is a type of DNA […]
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Photoreactivation : Method of DNA Repair for the Recovery of UV Induced DNA Damages by Phytolyase Enzyme and Visible Light
Science is beautiful when it makes simple explanations of phenomena or connections between different observations. Stephen W. Hawking, 2011 What is Photoreactivation? Photoreactivation is a type of DNA repair mechanism present in prokaryotes, archaea and in many eukaryotes. It is the recovery of ultraviolet irradiated damages of DNA by visible light. As the name suggests, it is a light dependent […]
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DNA Repair Mechanism – Part I Introduction (DNA Damaging Agents, DNA Damages and Recovery of DNA Damages)
“Genetic variation is important for evolution, but the survival of the individuals demand genetic stability” DNA is the genetic information carrier molecule in the cell and thus it is very essential to keep the genetic information intact. Even though DNA holds a prime position, it is one of the highly susceptible molecules in the cells because DNA can be damaged […]
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MCQ on DNA Repair Mechanisms in Prokaryotes and Eukaryotes
Molecular Biology MCQ-01: DNA repair is a cellular process that ensures the integrity and stability of the DNA molecule. The DNA in our cells can be damaged by various factors, including environmental agents such as radiation and chemicals, as well as internal cellular processes. If left unrepaired, DNA damage can lead to mutations, genomic instability, and potentially contribute to the […]
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