MCQ on Purine Synthesis (Nucleic Acid Biosynthesis)







Purine synthesis is a biochemical pathway that cells use to produce purine nucleotides, the building blocks of DNA and RNA. It involves a series of enzymatic reactions that convert precursor molecules into purines, such as adenine and guanine. This pathway is essential for the synthesis of genetic material and various cellular processes. This is an MCQ on purine synthesis and its significance.

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Learn more: Simplified Note on Nucleotide Biosynthesis

1. 
Purine synthesis is a metabolic pathway responsible for the de novo biosynthesis of purine nucleotides. Which of the following is NOT a purine base?

2. 
In purine synthesis, the first committed step is the conversion of PRPP (5-phosphoribosyl-1-pyrophosphate) to:

3. 
The rate-limiting enzyme in purine synthesis is:

4. 
The first purine nucleotide synthesized de novo in the pathway is:

5. 
Which enzyme converts IMP to XMP in the purine synthesis pathway?

6. 
The enzyme adenylosuccinate synthase catalyzes the conversion of:

7. 
The end product of the purine synthesis pathway is:

8. 
Which of the following compounds is an inhibitor of the purine synthesis pathway, specifically targeting the enzyme amidophosphoribosyltransferase?

9. 
The salvage pathway for purine synthesis involves the reuse of purine bases. Which enzyme is responsible for converting hypoxanthine to IMP in the salvage pathway?

10. 
Deficiencies in enzymes involved in the purine synthesis pathway can lead to metabolic disorders known as:

11. 
Which of the following molecules is a precursor in the purine synthesis pathway?

12. 
In the purine synthesis pathway, PRPP (5-phosphoribosyl-1-pyrophosphate) is formed from which molecule?

13. 
Which enzyme catalyzes the first committed step in de novo purine synthesis, converting PRPP to 5-phosphoribosylamine?

14. 
The synthesis of purine nucleotides is an energy-intensive process that requires:

15. 
Which of the following is a product of the purine degradation pathway?

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